Light controlled drugs to modulate neuronal activity locally and on-demand without systemic adverse effects.
PHOTOTHERAPORT PROJECT
We combine locally light-emitting implants and light-controlled drugs to get precise anti-inflammatory treatments by photobiomodulation and neuroinhibitory treatments by photopharmacology.
We’re at the forefront of medical innovation, exploring new frontiers in the treatment of neurological and inflammatory conditions. Our project combines cutting-edge technologies to offer precise and personalized therapeutic solutions that could change the way we approach health challenges.
PhotoTheraPorts IMPLANTS
Our flagship technology is the light-emitting implants, known as PhotoTheraPorts. These miniature light ports, guided by nanocrystals, act as light sources within our bodies. When exposed to invisible and non-invasive infrared light, they emit light in the visible spectrum.
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photoswitchable drugs
We're also developing photoswitchable drugs with anti-inflammatory and neuroinhibitory activity. These drugs will activate only when exposed to a specific color of light, acting as personalized light switches for the nervous system.
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PHOTOTHERAPORT PROJECT
Together, these advancements form the foundation of the PHOTOTHERAPORT Project and open up new possibilities for reducing pain and epileptic seizures in localized regions of the nervous system. During the project, we will conduct preclinical tests of the efficacy and safety of both devices and drugs.
Consortium
Institute for Bioengineering of Catalonia (IBEC)
Principal investigator: Pau Gorostiza
Photoswitchable drugs for multiple targets, activated by ultraviolet, red and infrared light
Tampereen Korkeakoulusaatio SR (TAU)
Principal investigator: Laeticia Petit
Biocompatible glass-based materials, upconverting nanoparticles, and luminescent crystals to build PhotoTheraPort implants
Riga Stradins University (RSU)
Principal investigator: Valērija Groma
Histology and photopharmacology of brain slices
TEAMIT INSTITUTE SL (TINS
Principal investigator: Gianmarco Di Mauro
Innovation, dissemination, and regulatory evaluation
Latvian Institute of Organic Synthesis (LIOS)
Principal investigator: Rossella Castagna
Polymeric matrices with tailor-made geometries, optical, and biocompatible properties to build PhotoTheraPort implants
University of Cádiz (UCA)
Principal investigator: Esther Berrocoso
Rodent models of inflammatory and neuropathic pain
TECHNION (TECH)
Principal investigator:Jackie Schiller
Electrophysiology and photopharmacology of brain slices
Institute of Biomedical Research Barcelona (IIBB-CSIC)
Principal investigator: Victoria Puig
Electrophysiology and photopharmacology in mouse models of neurological diseases
