In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.
Davia Prischich, Rosalba Sortino, Alexandre Gomila-Juaneda, Carlo Matera, Salvador Guardiola,
Diane Nepomuceno, Monica Varese, Pascal Bonaventure, Luis de Lecea, Ernest Giralt,
Pau Gorostiza.
Cellular and Molecular Life Sciences
https://doi.org/10.1007/s00018-024-05308-x
Photoswitchable Carbamazepine Analogs for Non-Invasive Neuroinhibition In Vivo.
Luisa Camerin, Galyna Maleeva, Alexandre M. J. Gomila, Irene Suárez-Pereira, Carlo Matera, Davia Prischich, Ekin Opar, Fabio Riefolo, Esther Berrocoso, and Pau Gorostiza.
Angewandte Chemie
https://doi.org/10.1002/anie.202403636
Brain state identification and neuromodulation to promote recovery of consciousness.
van der Lande, Glenn J M; Casas-Torremocha, Diana; Manasanch, Arnau; Dalla Porta, Leonardo; Gosseries, Olivia; Alnagger, Naji; Barra, Alice; Mejías, Jorge F; Panda, Rajanikant; Riefolo, Fabio; Thibaut, Aurore; Bonhomme, Vincent;
Brain Communications
https://doi.org/10.1093/braincomms/fcae362
Photo-BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor.
Hubert Gerwe, Eva Schaller, Rosalba Sortino, Ekin Opar, Joaquín Martínez-Tambella, Marcel Bermudez, J. Robert Lane, Pau Gorostiza and Michael Decker.
Angewandte Chemie
https://doi.org/10.1002/anie.202411438
Light-Activated Agonist-Potentiator of GABAA Receptors for Reversible Neuroinhibition in Wildtype Mice.
Maleeva, Galyna; Nin-Hill, Alba; Wirth, Ulrike; Rustler, Karin; Ranucci, Matteo; Opar, Ekin; Rovira, Carme; Bregestovski, Piotr; Zeilhofer, Hanns Ulrich; König, Burkhard; Alfonso-Prieto, Mercedes; Gorostiza, Pau.
Journal of the American Chemical Society
https://doi.org/10.1021/jacs.4c08446
Interconnected Pathways: Exploring Inflammation, Pain, and Cognitive Decline in Osteoarthritis.
Tarasovs, Mihails; Skuja, Sandra; Svirskis, Simons; Sokolovska, Liba; Vikmanis, Andris; Lejnieks, Aivars; Shoenfeld, Yehuda; Groma, Valerija.
International Journal of Molecular Sciences
https://doi.org/10.3390/ijms252211918
Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands.
José M Sanchez-Sanchez, Fabio Riefolo, Almudena Barbero-Castillo, Rosalba Sortino, Luca Agnetta, Arnau Manasanch, Carlo Matera, Miquel Bosch, Marta Forcella, Michael Decker, Pau Gorostiza, Maria V Sanchez-Vives.
PNAS Nexus
https://doi.org/10.1093/pnasnexus/pgaf009